Meet Us At WMIC

Meet BioInVision application specialists at the 2017 World Molecular Imaging Congress, Philadelphia from September 13-16, 2017. Learn how to use cryo-imaging to advance your research.

Latest Cryo-Imaging News


Case spinoff looks to commercialize cryo-imaging technology

MedCity News (Sep. 6, 2011) — A Case Western Reserve University spinoff is planning to commercialize its high-resolution imaging technology that allows preclinical researchers to see the exact location of single cells and displays the information in a 3-D reconstruction of a mouse. (More...)


New Imaging Device Enables Scientists to See Tumor Cells Traveling in the Brain

ScienceDaily (Aug. 26, 2011) — For the first time, scientists can see pathways to stop a deadly brain cancer in its tracks. Researchers at Case Western Reserve University School of Medicine have imaged individual cancer cells and the routes they travel as the tumor spreads. (More...)


Selected Publications on Cryo-Imaging

  1. M. Qutaish, K. Sullivant, S. M. Burden-Gulley, H. Lu, D. Roy, J. Wang, J. P. Basilion, S. M. Brady-Kalnay, and D. L. Wilson, "Cryo-image analysis of tumor cell migration, invasion, and dispersal in a mouse xenograft model of human glioblastoma multiforme," J Molecular Imaging and Biology (2011).
  2. M. Gargesha, M. Q. Qutaish, D. Roy, G. J. Steyer, M. Watanabe, and D. L. Wilson, "Visualization of color anatomy and molecular fluorescence in whole-mouse cryo-imaging," Comput. Med. Imaging Graph. 35, 195-205 (2011).
  3. D. Roy, E. Sloter, M. Watanabe, and D. Wilson, "Cryo-imaging in a toxicological study on mouse fetuses," Proceedings of SPIE Medical Imaging 2010: Biomedical Applications in Molecular, Structural, and Functional Imaging 7626, (2010)
  4. D. Roy, M. Gargesha, G. J. Steyer, P. Hakimi, R. W. Hanson, and D. L. Wilson, "Multi-scale characterization of the PEPCK-C mouse through 3D cryo-imaging," Int. J. Biomed. Imaging 2010, 105984 (2010).
  5. D. Roy, G. J. Steyer, M. Gargesha, M. E. Stone, and D. L. Wilson, "3D cryo-imaging: a very high-resolution view of the whole mouse," Anat. Rec. (Hoboken. ) 292, 342-351 (2009).
  6. G. J. Steyer, D. Roy, O. Salvado, M. E. Stone, and D. L. Wilson, "Cryo-Imaging of Fluorescently-Labeled Single Cells in a Mouse," Proc. Soc. Photo. Opt. Instrum. Eng 7262, 72620W-72620W8 (2009).
  7. M. Gargesha, M. Qutaish, D. Roy, G. Steyer, H. Bartsch, and D. L. Wilson, "Enhanced Volume Rendering Techniques for High-Resolution Color Cryo-Imaging Data," Proc. Soc. Photo. Opt. Instrum. Eng 7262, 72655V (2009).
  8. G. J. Steyer, D. Roy, O. Salvado, M. E. Stone, and D. L. Wilson, "Removal of out-of-plane fluorescence for single cell visualization and quantification in cryo-imaging," Ann. Biomed. Eng 37, 1613-1628 (2009).
  9. D. Wilson, D. Roy, G. Steyer, M. Gargesha, M. Stone, and E. McKinley, "Whole Mouse Cryo-Imaging," Proc. Soc. Photo. Opt. Instrum. Eng 6916, 69161I-69161I9 (2008).
  10. M. S. Nguyen, O. Salvado, D. Roy, G. Steyer, M. E. Stone, R. D. Hoffman, and D. L. Wilson, "Ex vivo characterization of human atherosclerotic iliac plaque components using cryo-imaging," J. Microsc. 232, 432-441 (2008).
  11. D. Roy, M. Breen, O. Salvado, M. Heinzel, E. McKinley, and D. Wilson, "Imaging system for creating 3D block-face cryo-images of whole mice," Proceedings of SPIE Medical Imaging 2006: Physiology, Function, and Structure from Medical Images 6143, (2006)