Meet Us At EMIM

Meet BioInVision application specialists at the 2021 EMIM Conference Thessaloniki, Greece from Mar 15-18, 2022. Learn how to use CryoViz Imaging to advance your research.

Latest CryoViz Imaging News


Optimized Imager Tracks Cancer, Stem Cells in Medical Research

NASA Health and Medicine (Spinoff 2018) — After earning his doctorate, Debashish Roy set about creating a business from the biological imaging device he’d helped invent as a graduate student. The system held promise for cancer and stem cell research, among other possible applications. But he soon realized he could use some help. (More...)


3D Rendering From MSC Bio-distribution Studies With BioInVision's CryoViz System

MERLIN Project News (Mar 3, 2016) — MERLIN is developing stem cell-based therapies that specifically target the inflammatory components of liver disease. Our partners BioInVision have developed a cryo-imaging system for 3D, microscopic imaging – the CryoViz instrument. (More...)


Case spinoff looks to commercialize cryo-imaging technology

MedCity News (Sep. 6, 2011) — A Case Western Reserve University spinoff is planning to commercialize its high-resolution imaging technology that allows preclinical researchers to see the exact location of single cells and displays the information in a 3-D reconstruction of a mouse. (More...)


New Imaging Device Enables Scientists to See Tumor Cells Traveling in the Brain

ScienceDaily (Aug. 26, 2011) — For the first time, scientists can see pathways to stop a deadly brain cancer in its tracks. Researchers at Case Western Reserve University School of Medicine have imaged individual cancer cells and the routes they travel as the tumor spreads. (More...)


Selected Publications on CryoViz Imaging

  1. MacCannell, Amanda DV, et al. "Identification of a lipid-rich depot in the orbital cavity of the 13-lined ground squirrel." Journal of Experimental Biology (2019): jeb-195750.
  2. Sheehan, Gerard, and Kevin Kavanagh. "Proteomic Analysis of the Responses of Candida albicans during Infection of Galleria mellonella Larvae." Journal of Fungi 5.1 (2019): 7.
  3. Zhang, Qi, Terry Peters, and Aaron Fenster. "Layer-based visualization and biomedical information exploration of multi-channel large histological data." Computerized Medical Imaging and Graphics (2019).
  4. Ngo, Lucy, Lillian E. Knothe, and Melissa L. Knothe Tate. "Knee Joint Tissues Effectively Separate Mixed Sized Molecules Delivered in a Single Bolus to the Heart." Scientific reports 8.1 (2018): 10254.
  5. Parkins, Katie M., et al. "Multimodality cellular and molecular imaging of concomitant tumour enhancement in a syngeneic mouse model of breast cancer metastasis." Scientific reports8.1 (2018): 8930.
  6. Sheehan, Gerard, Gráinne Clarke, and Kevin Kavanagh. "Characterisation of the cellular and proteomic response of Galleria mellonella larvae to the development of invasive aspergillosis." BMC microbiology 18.1 (2018): 63.
  7. Qutaish, Mohammed Q., et al. "Cryo-Imaging and Software Platform for Analysis of Molecular MR Imaging of Micrometastases." International journal of biomedical imaging2018 (2018).
  8. Carty, Fiona, et al. "Multipotent adult Progenitor cells suppress T cell activation in In Vivo Models of homeostatic Proliferation in a Prostaglandin e2-Dependent Manner." Frontiers in immunology 9 (2018).
  9. de Witte, Samantha FH, et al. "Immunomodulation by therapeutic mesenchymal stromal cells (MSC) is triggered through phagocytosis of MSC by monocytic cells." Stem Cells36.4 (2018): 602-615.
  10. Wu, Chunying, et al. "Discovery of 1, 2, 3-Triazole Derivatives for Multimodality PET/CT/Cryoimaging of Myelination in the Central Nervous System." Journal of medicinal chemistry 60.3 (2017): 987-999.
  11. Perera, V. S., et al. "One-pot synthesis of nanochain particles for targeting brain tumors." Nanoscale 9.27 (2017): 9659-9667.
  12. de Witte, Samantha FH, et al. "Cytokine treatment optimises the immunotherapeutic effects of umbilical cord-derived MSC for treatment of inflammatory liver disease." Stem Cell Research & Therapy 8.1 (2017): 140.
  13. Prabhu, David, et al. "Three-dimensional registration of intravascular optical coherence tomography and cryo-image volumes for microscopic-resolution validation." Journal of Medical Imaging 3.2 (2016): 026004.
  14. Parkins, Katie M., et al. "A multimodality imaging model to track viable breast cancer cells from single arrest to metastasis in the mouse brain." Scientific reports 6 (2016): 35889.
  15. Saat, T. C., et al. "Fate and effect of intravenously infused mesenchymal stem cells in a mouse model of hepatic ischemia reperfusion injury and resection." Stem cells international 2016 (2016).
  16. Schmuck, Eric G., et al. "Biodistribution and Clearance of Human Mesenchymal Stem Cells by Quantitative Three-Dimensional Cryo-Imaging After Intravenous Infusion in a Rat Lung Injury Model." Stem Cells Translational Medicine (2016): sctm-2015.
  17. Kobes, Joseph E., et al. "Improved Treatment of Pancreatic Cancer With Drug Delivery Nanoparticles Loaded With a Novel AKT/PDK1 Inhibitor." Pancreas 45.8 (2016): 1158-1166.
  18. Wuttisarnwattana, Patiwet, et al. "Automatic stem cell detection in microscopic whole mouse cryo-imaging." IEEE transactions on medical imaging 35.3 (2016): 819-829.
  19. Zanotti, Lucia, et al. "Mouse mesenchymal stem cells inhibit high endothelial cell activation and lymphocyte homing to lymph nodes by releasing TIMP-1."Leukemia (2016).
  20. Doolittle, Elizabeth, et al. "Spatiotemporal targeting of a dual-ligand nanoparticle to cancer metastasis." ACS nano 9.8 (2015): 8012-8021.
  21. DePaul, Marc A., et al. "Intravenous multipotent adult progenitor cell treatment decreases inflammation leading to functional recovery following spinal cord injury." Scientific reports 5 (2015).
  22. Auletta, Jeffery J., et al. "Human Mesenchymal Stromal Cells Attenuate Graft‐Versus‐Host Disease and Maintain Graft‐Versus‐Leukemia Activity Following Experimental Allogeneic Bone Marrow Transplantation." Stem cells33.2 (2015): 601-614.
  23. Zhou, Zhuxian, et al. "MRI detection of breast cancer micrometastases with a fibronectin-targeting contrast agent." Nature communications 6 (2015).
  24. Qutaish, Mohammed Q., et al. "Cryo-image analysis of tumor cell migration, invasion, and dispersal in a mouse xenograft model of human glioblastoma multiforme." Molecular Imaging and Biology 14.5 (2012): 572-583.
  25. Burden-Gulley, Susan M., et al. "Novel cryo-imaging of the glioma tumor microenvironment reveals migration and dispersal pathways in vivid three-dimensional detail." Cancer research 71.17 (2011): 5932-5940.
  26. Gargesha, Madhusudhana, et al. "Visualization of color anatomy and molecular fluorescence in whole-mouse cryo-imaging." Computerized Medical Imaging and Graphics 35.3 (2011): 195-205.
  27. Roy, Debashish, et al. "Multi-scale characterization of the PEPCK-C mus mouse through 3D Cryo-imaging." Journal of Biomedical Imaging 2010 (2010): 5.
  28. Steyer, Grant J., et al. "Removal of out-of-plane fluorescence for single cell visualization and quantification in cryo-imaging." Annals of biomedical engineering 37.8 (2009): 1613-1628.
  29. Roy, Debashish, et al. "3D cryo‐imaging: a very high‐resolution view of the whole mouse." The anatomical record 292.3 (2009): 342-351.
  30. Nguyen, M. S., et al. "Ex vivo characterization of human atherosclerotic iliac plaque components using cryo‐imaging." Journal of microscopy 232.3 (2008): 432-441.