Meet Us At WMIC

Meet BioInVision application specialists at the 2017 World Molecular Imaging Congress, Philadelphia from September 13-16, 2017. Learn how to use cryo-imaging to advance your research.

About BioInVision

BioInVision brings its expertise in high-resolution, large field-of-view microscopic imaging, 3D reconstruction, and specialized image processing and analysis capabilities, to solve Biotechnology problems. Data sizes for many applications routinely exceed 60GB and specialized hardware and software has been developed to provide a rich multi-scale interactive visualization experience to the user. The company's core competency is in cryo-imaging which was originally developed at Case Western Reserve University and licensed exclusively to BioInVision.

BioInVision is continuing to develop applications and algorithms for the pre-clinical market and has won several competitive awards from NIH and other agencies. These awards are being used to grow applications of cryo-imaging in stem cells, toxicology, and nanoparticle imaging agent/drug delivery. The company is also currently a consortium partner in an awarded Ohio Third Frontier Project.

Two of the principals of the company are co-inventors of the technology. Debashish Roy, PhD is the President of the company and is a specialist in block-face imaging, biomedical image processing and analysis. He has over 10 years of experience as engineering project manager and technical sales lead for major multi-national corporations. David Wilson, PhD is the founder and CTO. He is also the Herbold Professor of Biomedical Engineering at Case Western Reserve University. Prior to joining academia he worked for Siemens Medical systems and setup several medical imaging systems. He is an expert in biomedical imaging with over 90 journal publications.

BioInVision is based in Cleveland, Ohio.

Cryo-Imaging Technology

BioInVision, Inc. and Case Western Reserve University researchers have developed a cryo-imaging system for 3D, microscopic imaging of whole mice or organs. With the patented cryo-imaging technology, one can detect and spatially map nearly every stem cell in an organ or mouse, providing a unique ability to evaluate homing/engraftment. Cryo-imaging is ideal for addressing the almost ubiquitous question in stem cell therapy and cancer applications, “Where did my cells go?” In addition, with differentiation reporter genes, one has an opportunity to map identify those cells which have undergone differentiation in vivo. The cryo-imaging system consists of a modified, bright-field/fluorescence microscope; a robotic imaging system positioner; a customized, whole mouse motorized cryostat; control system; and analysis/visualization software. By alternately sectioning and imaging, the system acquires from sequential images of the tissue block face, 3D color, and fluorescence image volumes exceeding 60 GB of image data. With multi-scale volume rendering, one obtains exquisite views of anatomy as well as molecular fluorescence volumes showing locations of molecules and/or cells. In addition to stem cells and regenerative medicine, cryo-imaging serves very many applications in biological research and commercial biotechnology, including mouse anatomical phenotyping, nanoparticle drug delivery, metastatic cancer, immune system response, etc. Cryo-imaging is unique among all in vivo and microscopic techniques in that it allows micron resolution and information-rich contrast mechanisms over very large 3D fields of view. It fills the gap between whole animal in vivo imaging and histology, allowing one to image a mouse along the continuum from the mouse -> organ -> tissue structure -> cell -> sub-cellular domains.

Some of the application areas of Cryo-imaging include:

Please contact us with your specific application.